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1985 2
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2008 2
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Page 1
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
Hoffman JL, Faccidomo S, Kim M, Taylor SM, Agoglia AE, May AM, Smith EN, Wong LC, Hodge CW. Hoffman JL, et al. Int Rev Neurobiol. 2019;148:169-230. doi: 10.1016/bs.irn.2019.10.017. Epub 2019 Oct 23. Int Rev Neurobiol. 2019. PMID: 31733664 Free PMC article. Review.
To address the impact of alcohol drinking on AD, studies were conducted using 3xTg-AD mice that express human MAPT, APP, and PSEN-1 transgenes and develop AD-like brain and behavioral pathology. 3xTg-AD and wild-type mice consumed alcohol or saccharin for 4 months. ...Resu …
To address the impact of alcohol drinking on AD, studies were conducted using 3xTg-AD mice that express human MAPT, APP, and PSEN-1 transgen …
The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation.
Zhang H, Liu Y, Li Y, Zhou Y, Chen D, Shen J, Yan Y, Yan S, Wu X, Li A, Guo A, Cheng C. Zhang H, et al. J Mol Neurosci. 2014 Dec;54(4):653-63. doi: 10.1007/s12031-014-0363-y. Epub 2014 Jul 25. J Mol Neurosci. 2014. PMID: 25060335
However, the distribution and function of CAP1 in the central nervous system (CNS) remain unclear. To investigate whether CAP1 is involved in CNS injury and repair, we used an acute traumatic brain injury (TBI) model in adult rats. ...In addition, we detected …
However, the distribution and function of CAP1 in the central nervous system (CNS) remain unclear. To investigate whether CAP1 …
Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma.
Fan YC, Cui CC, Zhu YS, Zhang L, Shi M, Yu JS, Bai J, Zheng JN. Fan YC, et al. Oncol Rep. 2016 Sep;36(3):1619-25. doi: 10.3892/or.2016.4936. Epub 2016 Jul 13. Oncol Rep. 2016. PMID: 27432289
Nevertheless, the expression level and effects of CAP1 in regards to glioma have not been reported. In the present study, we examined the expression of CAP1 in glioma and tumor adjacent normal brain tissues by tissue microarray and immunohistochemistry. Our r …
Nevertheless, the expression level and effects of CAP1 in regards to glioma have not been reported. In the present study, we examined …
Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
Schneider F, Metz I, Khudayberdiev S, Rust MB. Schneider F, et al. Cells. 2021 Jun 17;10(6):1525. doi: 10.3390/cells10061525. Cells. 2021. PMID: 34204261 Free PMC article.
We recently reported crucial roles for CAP1 in growth cone function, neuron differentiation, and neuron connectivity in the mouse brain. ...Moreover, CAP2 mutant mice did not display any obvious changes in brain anatomy. Hence, differently from CAP1, C …
We recently reported crucial roles for CAP1 in growth cone function, neuron differentiation, and neuron connectivity in the mouse …
Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology.
Heinze A, Schuldt C, Khudayberdiev S, van Bommel B, Hacker D, Schulz TG, Stringhi R, Marcello E, Mikhaylova M, Rust MB. Heinze A, et al. Cell Mol Life Sci. 2022 Oct 20;79(11):558. doi: 10.1007/s00018-022-04593-8. Cell Mol Life Sci. 2022. PMID: 36264429 Free PMC article.
Mechanistically, we found that CAP1 cooperates with cofilin1 in spines and that its helical folded domain is relevant for this interaction. Moreover, our data proved functional interdependence of CAP1 and cofilin1 in control of spine morphology. In summary, we ident …
Mechanistically, we found that CAP1 cooperates with cofilin1 in spines and that its helical folded domain is relevant for this intera …
Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function.
Schneider F, Duong TA, Metz I, Winkelmeier J, Hübner CA, Endesfelder U, Rust MB. Schneider F, et al. Prog Neurobiol. 2021 Jul;202:102050. doi: 10.1016/j.pneurobio.2021.102050. Epub 2021 Apr 18. Prog Neurobiol. 2021. PMID: 33845164 Free article.
Hence, actin binding proteins (ABPs) moved into the focus as critical regulators of neuron connectivity. We found cyclase-associated protein 1 (CAP1), an ABP with unknown brain function, abundant in growth cones. ...Growth cone defects in CAP1 knockout (KO) n …
Hence, actin binding proteins (ABPs) moved into the focus as critical regulators of neuron connectivity. We found cyclase-associated protein …
Disease association of cyclase-associated protein (CAP): Lessons from gene-targeted mice and human genetic studies.
Rust MB, Marcello E. Rust MB, et al. Eur J Cell Biol. 2022 Apr;101(2):151207. doi: 10.1016/j.ejcb.2022.151207. Epub 2022 Feb 8. Eur J Cell Biol. 2022. PMID: 35150966 Free article. Review.
In all vertebrates and some invertebrate species, two orthologs, named CAP1 and CAP2, have been described. CAP1 and CAP2 are characterized by a similar multidomain structure, but different expression patterns. ...
In all vertebrates and some invertebrate species, two orthologs, named CAP1 and CAP2, have been described. CAP1 and CAP2 are c …
Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity.
Heinze A, Rust MB. Heinze A, et al. Eur J Cell Biol. 2023 Dec;102(4):151357. doi: 10.1016/j.ejcb.2023.151357. Epub 2023 Aug 24. Eur J Cell Biol. 2023. PMID: 37634312 Free article.
We found that induction of both forms of synaptic plasticity oppositely altered concentration of exogenous, myc-tagged CAP1 in dendritic spines, with chemical LTP (cLTP) decreasing and chemical LTD (cLTD) increasing it. cLTP induced spine enlargement in CAP1-deficie …
We found that induction of both forms of synaptic plasticity oppositely altered concentration of exogenous, myc-tagged CAP1 in dendri …
Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis.
Udhaya Kumar S, Datta A, Gnanasambandan R, Younes S, Medha T, Siva R, George Priya Doss C, Zayed H. Udhaya Kumar S, et al. Adv Protein Chem Struct Biol. 2022;131:235-259. doi: 10.1016/bs.apcsb.2022.05.003. Epub 2022 Jun 22. Adv Protein Chem Struct Biol. 2022. PMID: 35871892
Gene expression profiling of the microarray dataset GSE38010 was used to analyze two control brain samples (control 1; GSM931812, control 2; GSM931813), active inflammation stage samples (CAP1; GSM931815, CAP2; GSM931816) and late subsided stage samples (CP1; GSM931 …
Gene expression profiling of the microarray dataset GSE38010 was used to analyze two control brain samples (control 1; GSM931812, con …
42 results